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Frey in 1989 [30, 31] represents a non-invasive method for bypassing the BBB via the olfactory route

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Based on the fitted pKa of 6.87, which is in good agreement with the average of 6.52 from other reported values (11, 57–59), the amount of niclosamide in aqueous solution increases in the higher pH range (of 8-9.5)