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Injectable vitamin B-12, which is used to treat significant deficiencies, can cause the following side effects: mild diarrhea itching skin rash headache dizziness nausea vomiting pulmonary edema and congestive heart failure early in treatment vein thrombosis sensation of swelling polycythemia vera (rare, slow-growing blood cancer) Vitamin B-12 can cause very rare but severe allergic reactions (anaphylaxis)

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