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The downstream effects are distinct from incretin signaling: slowing of gastric emptying, suppression of postprandial glucagon, and reduction of food intake through central satiety circuits that do not heavily overlap with GLP-1 pathways

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The reality of oral administration for musculoskeletal indications is straightforward: the peptide disperses through the digestive system before it reaches the injury site, and what arrives at a tendon or joint after that journey is a fraction of what a subcutaneous injection placed near the tissue delivers