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In asthma, allergen-induced protein misfolding (e.g., ovalbumin aggregates) triggers Golgi stress, activating the Golgi stress response (GSR) (111) Persistent Golgi stress response (GSR) upregulates NADPH oxidase 4 (NOX4) within the Golgi apparatus, leading to a substantial increase in localized ROS production

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SF has also demonstrated anxiolytic effects, particularly in models where anxiety is linked to chronic pain and neurodegenerative conditions [184,186]