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However, in-person programs provide direct medical supervision and immediate adverse event management, potentially justifying higher costs for patients with complex medical histories or multiple comorbidities.

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Earlier, the only head-to-head comparison available came from the phase 2 dose-finding trial, where cagrilintide 4.5 mg produced a 10.8% reduction versus 9.0% with liraglutide 3.0 mg over 26 weeks (estimated difference 1.8%, p=0.03) — a modest margin over an approved comparator, on the trial product estimand (Lau et al., 2021)