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[9] Numeric pain scales like Patients’ Global Impression of Change scale and Likert-type pain intensity scale have shown remarkable improvement in pain symptoms due to methylcobalamin neuralgia.[10] It not only reduces the pain symptoms but also ensures improved quality of life.[11] Neuroprotection and Neuro-synthesis The majority of therapeutic activity of methylcobalamin is in the form of an analgesic and regulator of homocysteine is due to its positive role in promoting the action and structure of nerve cells as well as providing mechanisms for regeneration of damaged neurons.[12] Methylcobalamin functions to restore the integrity and strength of the myelin sheath resulting in increased neuroprotection and improved neural conductance