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A 2026 review of approved and unapproved peptide therapies for musculoskeletal injuries places this group among materials with an unconfirmed effectiveness profile (Mendias and Awan, 2026, PMID 41966639)

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What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint