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The regulations at 42 CFR 412.85(c) also specify that the adjustment factor will reflect the average cost for cases to be assigned to MS-DRG 018 that involve expanded access use of immunotherapy or are part of an applicable clinical trial to the average cost for cases to be assigned to MS-DRG 018 that do not involve expanded access use of immunotherapy and are not part of a clinical trial (85 FR 58844)

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These early studies were quickly overshadowed by the subsequent discovery of the β-cell ATP-sensitive K + (K ATP ) channel (Cook and Hales, 1984), which provided a mechanism to explain how the plasma membrane responds to glucose metabolism and controls the timing of Ca 2+ influx and insulin secretion (Ashcroft et al., 1984