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These results indicate that other post-translational modification factors including microRNA (miRNA) might regulate SIRT1 and PGC-1α at the transcriptional level 60,61,62,63

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Some small scale preliminary studies suggested that flavor-enhancing chemicals like MSG and hydrogenated fats in diet or, more precisely, ready-made foods are the dietary operators of altered expression of a gene that developed disease with a term of phenotype in psoriasis and hypertensive human [[269], [270], [271], [272]]