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Additionally, the LMOP group demonstrated higher drug permeation and prolonged local retention, not only improving the treatment effect of vitiligo but also reducing systemic adverse effects by limiting drug entry into the bloodstream

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After declining Upjohn permission to market topical minoxidil as a non-prescription drug in July 1994, the 2% topical solution was subsequently approved for over-the-counter use in men with alopecia in February 1996