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The peptide was originally believed to be involved in sleep regulation because it appeared to induce slow-wave sleep in rabbits, but as that same source notes, "studies on the subject have been contradictory." DSIP has low molecular stability in vitro, with a half-life reported at about 15 minutes, attributed to a specific aminopeptidase-like enzyme

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[88] found the same relationship in animal models when studying reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP), noting the effective antioxidant defense of newborns, who often coped with ROS better than their mothers