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Since the 1990s, along with continued elucidation of the mechanism of neurodegeneration induced by oxidative stress in the CNS, GSH depletion in the brains of patients with neurodegenerative diseases has been increasingly reported

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Macrophages act as frontline innate immune cells through pathogen recognition, phagocytosis, and cytokine secretion, whereas lymphocytes, including T and B cells, coordinate adaptive immune responses