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[PMC free article: PMC3010674] [PubMed: 21197150] (A systematic review of published randomized controlled trials of HCA as a weight loss agent identified 12 studies with a total of 706 subjects, found evidence of a slight effect [-0.9 kg] that was marginally significant compared to placebo while adverse events were similar between the two groups

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Daily dosing would risk supratherapeutic accumulation and is not supported by the published pharmacokinetic data