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doi: 10.3389/fphar.2025.1702452 Received 10 September 2025 Revised 17 November 2025 Accepted 19 November 2025 Published 04 December 2025 Volume 16 - 2025 Edited by Piyush Kumar Gupta, Sharda University, India Reviewed by Anurag Kumar Singh, Indian Institute of Technology, Varanasi, India Zhen Ye, Chengdu University of Traditional Chinese Medicine, China Updates Copyright © 2025 Zhou, Xing, Zhang and Zhang

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That deep inflammation presses directly on nerve endings, which is why it throbs and causes real pain in a way surface breakouts never do