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f-j , Volcano plot of metabolic differences ( f) and levels of GSSG (g) , ophthalmic acid (h) , glutamate (i) , cysteine (NEM-cysteine) (j) from Gclc WT and Gclc KO tumors

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In contrast, adult-onset deletion of the Keap1 gene exclusively in renal tubular cells caused no abnormalities in renal structure or function [67], demonstrating that overactivation of Nrf2 in the mature renal epithelium makes kidneys resistant to oxidative injuries without any significant abnormalities