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this model is static PES improves separation but remains a single perturbation snapshot MEA captures correlates of state transitions, not full continuous dynamics This paper shows local cortical dynamics only (not whole-brain physiology) so results are: 👉developmental-stage dependent 👉model-specific (2D ≠ organoid ≠ in vivo brain) 👉perturbation-dependent ❓Why fully dynamic modeling is nearly impossible

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This has led to widespread implementation of supplementation and fortification programs in staple foods across several countries (60)