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It should be noted that the therapeutic concepts discussed herein—including mitochondria-targeted drug delivery, organelle transplantation and genome editing—remain predominantly preclinical, and the translation of these strategies into clinically validated disease-modifying therapies will require rigorous demonstration of safety, efficacy and reproducibility in human studies

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Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy