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This leads to dose-dependent weight loss (typically 8-15% in monotherapy trials), with additive effects when combined with GLP-1 agonists like semaglutide due to complementary mechanisms on energy balance and gastrointestinal function

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Preclinical safety data does not always predict human safety outcomes, and the absence of adverse effects in controlled animal studies does not guarantee the same in diverse human populations with varying health conditions and concurrent medications