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The mechanism of action, while increasingly understood, involves complexities that continue to challenge researchers

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MPL data provide key information about the number of monomers in a β-sheet layer (∼0.47 nm) thus allowing to decipher the composition of fibril layers, like in n-fold Aβ filaments or the two windings of the HET-s β-solenoid ( As an increasing list of complex amyloid fibril arrangements is being studied, integrative hybrid approaches for structural determination that combine data from various sources are becoming more relevant (Röder et al., 2019