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Glutathione deficiency alters the vitamin D-metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of HFD-fed mice - ScienceDirect

albicans infection, Gsr −/− mice exhibited dramatically increased fungal burden in the kidneys, cytokine and chemokine storm, striking neutrophil infiltration and histological abnormalities in both the kidneys and hearts, and substantially elevated mortality

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Category 2 includes substances that raise significant safety or efficacy concerns, meaning they generally cannot be used in compounding unless specific criteria are met